|Application ||WB, E|
|Calculated MW||79435 Da|
|Antigen Region||380-409 aa|
|Other Names||Testis-specific Y-encoded-like protein 2, TSPY-like protein 2, Cell division autoantigen 1, Cutaneous T-cell lymphoma-associated antigen se20-4, CTCL-associated antigen se20-4, Differentially-expressed nucleolar TGF-beta1 target protein, Nuclear protein of 79 kDa, NP79, TSPYL2, CDA1, DENTT, TSPX|
|Target/Specificity||This TSPYL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-409 amino acids from the Central region of human TSPYL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TSPYL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CDA1, DENTT, TSPX|
|Function||Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.|
|Cellular Location||Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons|
|Tissue Location||Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
Dephoure N., et al. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Chai Z., et al. J. Biol. Chem. 276:33665-33674(2001).
Eichmueller S., et al. Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001).
Bechtel S., et al. BMC Genomics 8:399-399(2007).
Ross M.T., et al. Nature 434:325-337(2005).
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