|Application ||WB, E|
|Other Accession||Q2HXW4, O09118, Q90922|
|Predicted||Chicken, Mouse, Pig|
|Calculated MW||67748 Da|
|Antigen Region||568-596 aa|
|Other Names||Netrin-1, Epididymis tissue protein Li 131P, NTN1, NTN1L|
|Target/Specificity||This NTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 568-596 amino acids from the C-terminal region of human NTN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NTN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335).|
|Cellular Location||Secreted. Cytoplasm. Note=Mainly secreted|
|Tissue Location||Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Meyerhardt J.A., et al. Cell Growth Differ. 10:35-42(1999).
Zody M.C., et al. Nature 440:1045-1049(2006).
Li J., et al. Mol. Cell. Proteomics 9:2517-2528(2010).
Mazelin L., et al. Nature 431:80-84(2004).
Liu G., et al. Proc. Natl. Acad. Sci. U.S.A. 106:2951-2956(2009).
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