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R Cask Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q62915 |
| Other Accession | O70589, O14936 |
| Reactivity | Rat |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 103259 Da |
| Antigen Region | 589-616 aa |
| Gene ID | 29647 |
|---|---|
| Other Names | Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase, Cask |
| Target/Specificity | This Rat Cask antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of rat Cask. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | R Cask Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Cask {ECO:0000312|RGD:62004} |
|---|---|
| Function | Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (By similarity). Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking.ontributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein |
| Tissue Location | Expressed in the foot process layer of podocytes in the kidney glomerulus and in tubules (at protein level). Detected in brain and neurons. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
References
Hata Y., et al. J. Neurosci. 16:2488-2494(1996).
Butz S., et al. Cell 94:773-782(1998).
Hsueh Y.P., et al. Nature 404:298-302(2000).
Tabuchi K., et al. J. Neurosci. 22:4264-4273(2002).
Chetkovich D.M., et al. J. Neurosci. 22:6415-6425(2002).
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