|Application ||WB, E|
|Calculated MW||69506 Da|
|Antigen Region||147-179 aa|
|Other Names||Prolactin receptor, PRL-R, PRLR|
|Target/Specificity||This PRLR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-179 amino acids from the Central region of human PRLR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRLR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in breast, placenta, kidney, liver and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Boutin J.-M., et al. Mol. Endocrinol. 3:1455-1461(1989).
Kline J.B., et al. J. Biol. Chem. 274:35461-35468(1999).
Hu Z.-Z., et al. J. Clin. Endocrinol. Metab. 84:1153-1156(1999).
Hu Z.Z., et al. J. Biol. Chem. 276:41086-41094(2001).
Kline J.B., et al. Mol. Endocrinol. 16:2310-2322(2002).
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