|Application ||WB, E|
|Other Accession||Q15743, O46685|
|Calculated MW||41209 Da|
|Antigen Region||200-225 aa|
|Other Names||Ovarian cancer G-protein coupled receptor 1, G-protein coupled receptor 68, Sphingosylphosphorylcholine receptor, Gpr68, Ogr1|
|Target/Specificity||This Mouse Gpr68 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-225 amino acids from the Central region of mouse Gpr68.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||M Gpr68 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in the lung, testis, heart, brain, spleen, thymus, brown fat, small intestine, colon, peripheral blood leukocytes, macrophages, stomach, ovary and white fat but not in the liver, kidney, and skeletal muscle. Expression in the prostate is weak but detectable.|
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Provided below are standard protocols that you may find useful for product applications.
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer.
Carninci P., et al. Science 309:1559-1563(2005).
Vassilatis D.K., et al. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
Singh L.S., et al. J. Natl. Cancer Inst. 99:1313-1327(2007).
Frick K.K., et al. J. Bone Miner. Res. 24:305-313(2009).
Li H., et al. PLoS ONE 4:E5705-E5705(2009).
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