|Application ||IHC-P, WB, E|
|Other Accession||Q9D8Y8, Q8WYH8, Q8C0D7, Q5ZKY4, Q3T095|
|Predicted||Bovine, Chicken, Mouse|
|Calculated MW||28530 Da|
|Other Names||Inhibitor of growth protein 4, p29ING4, ING4|
|Target/Specificity||This ING4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the C-terminal region of human ING4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ING4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).|
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Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).
Shiseki M.,et al.Cancer Res. 63:2373-2378(2003).
Unoki M.,et al.J. Biol. Chem. 281:34677-34686(2006).
Raho G.,et al.Oncogene 26:5247-5257(2007).
Mao Y.M.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
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