|Application ||WB, E|
|Calculated MW||43692 Da|
|Other Names||Regulator of G-protein signaling 20, RGS20, Gz-selective GTPase-activating protein, G(z)GAP, Gz-GAP, Regulator of G-protein signaling Z1, Regulator of Gz-selective protein signaling 1, RGS20, RGSZ1, ZGAP1|
|Target/Specificity||This RGS20 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 150-184 amino acids from the Central region of human RGS20.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RGS20 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)- i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).|
|Cellular Location||Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus Anchored to the membrane through palmitoylation.|
|Tissue Location||Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe|
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Provided below are standard protocols that you may find useful for product applications.
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
Wang J.,et al.J. Biol. Chem. 273:26014-26025(1998).
Wang J.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Barker S.A.,et al.Genomics 78:223-229(2001).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Glick J.L.,et al.J. Biol. Chem. 273:26008-26013(1998).
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