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TUFM Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IF, WB, E |
|---|---|
| Primary Accession | P49411 |
| Other Accession | P85834, Q8BFR5, P49410 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49875 Da |
| Gene ID | 7284 |
|---|---|
| Other Names | Elongation factor Tu, mitochondrial, EF-Tu, P43, TUFM |
| Target/Specificity | This TUFM antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 112-147 amino acids from the N-terminal region of human TUFM. |
| Dilution | IF~~1:25 WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TUFM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TUFM |
|---|---|
| Function | GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. |
| Cellular Location | Mitochondrion. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
References
Woriax V.L.,et al.Biochim. Biophys. Acta 1264:347-356(1995).
Wells J.,et al.FEBS Lett. 358:119-125(1995).
Ling M.,et al.Gene 197:325-336(1997).
Martin J.,et al.Nature 432:988-994(2004).
Dunn M.J.,et al.Submitted (MAR-1996) to UniProtKB.
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