- CITATIONS: 4
|Application ||WB, E|
|Calculated MW||133277 Da|
|Other Names||Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1, JAK1, JAK1A, JAK1B|
|Target/Specificity||This JAK1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 172-204 amino acids from the N-terminal region of human JAK1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||JAK1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:8232552, PubMed:7615558, PubMed:28111307, PubMed:32750333, PubMed:16239216). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:8232552, PubMed:7615558, PubMed:28111307, PubMed:32750333, PubMed:16239216). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:8232552, PubMed:16239216, PubMed:32750333).|
|Cellular Location||Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated|
|Tissue Location||Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue|
Provided below are standard protocols that you may find useful for product applications.
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
Wilks A.F.,et al.Mol. Cell. Biol. 11:2057-2065(1991).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Lee S.-T.,et al.Oncogene 8:3403-3410(1993).
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