|Application ||WB, E|
|Calculated MW||24115 Da|
|Other Names||E3 ubiquitin-protein ligase ZNRF2, 632-, Protein Ells2, RING finger protein 202, Zinc/RING finger protein 2, ZNRF2, RNF202|
|Target/Specificity||This ZNRF2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2-36 amino acids from the N-terminal region of human ZNRF2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNRF2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.|
|Cellular Location||Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein|
|Tissue Location||Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Araki T.,et al.J. Neurosci. 23:9385-9394(2003).
Guo J.H.,et al.Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
Olsen J.V.,et al.Cell 127:635-648(2006).
Plans V.,et al.J. Cell. Biochem. 97:572-582(2006).
Cantin G.T.,et al.J. Proteome Res. 7:1346-1351(2008).
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