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SERAC1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96JX3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 74147 Da |
| Gene ID | 84947 |
|---|---|
| Other Names | Protein SERAC1, Serine active site-containing protein 1, SERAC1 |
| Target/Specificity | This SERAC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 41-64 amino acids from the N-terminal region of human SERAC1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SERAC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SERAC1 |
|---|---|
| Function | Facilitates the transport of serine from the cytosol to the mitochondria by interacting with and stabilizing Sideroflexin-1 (SFXN1), a mitochondrial serine transporter, playing a fundamental role in the one-carbon cycle responsible for the synthesis of nucleotides needed for mitochondrial DNA replication (PubMed:35235340). Plays an important role in the phosphatidylglycerol (PG) remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking (PubMed:22683713). Specifically involved in the exchange of the sn-1 acyl chain from PG 16:0/18:1(9Z) (also known as 1- hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)) to PG 18:0/18:1(9Z) (also known as 1-octadecanoyl-2-(9Z-octadecenoyl)- sn-glycero-3-phospho-(1'-sn-glycerol)), a step needed in the bis(monoacylglycerol)phosphate biosynthetic pathway (PubMed:22683713). May have acyltransferase activity although the mechanism for PG remodeling has not been determined (PubMed:22683713). |
| Cellular Location | Mitochondrion membrane {ECO:0000250|UniProtKB:Q3U213}; Single-pass membrane protein. Endoplasmic reticulum Mitochondrion. Note=Localizes at the endoplasmic reticulum and at the endoplasmic reticulum-mitochondria interface. |
| Tissue Location | Widely expressed, with predominant expression in skeletal muscle and brain (PubMed:22683713, PubMed:35235340). In the brain, highest levels are found in the frontal and occipital cortices, cerebellum and hippocampus (PubMed:22683713) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation- acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Tort F.,et al.Mol. Genet. Metab. 110:73-77(2013).
Wortmann S.B.,et al.Nat. Genet. 44:797-802(2012).
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