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HUMAN-RIN1(Y36) Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13671 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 84099 Da |
| Gene ID | 9610 |
|---|---|
| Other Names | Ras and Rab interactor 1, Ras inhibitor JC99, Ras interaction/interference protein 1, RIN1 |
| Target/Specificity | This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 20-70 amino acids from human. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HUMAN-RIN1(Y36) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RIN1 |
|---|---|
| Function | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. |
| Cellular Location | Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated |
| Tissue Location | Expressed in all tissues examined with high levels in brain, placenta and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
References
Colicelli J.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:2913-2917(1991).
Han L.,et al.Mol. Cell. Biol. 15:1318-1323(1995).
Han L.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:4954-4959(1997).
Afar D.E.H.,et al.Immunity 6:773-782(1997).
Tall G.G.,et al.Dev. Cell 1:73-82(2001).
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