|Application ||WB, E|
|Calculated MW||59093 Da|
|Other Names||Serine/threonine-protein kinase RIO3, RIO kinase 3, sudD homolog, RIOK3, SUDD|
|Target/Specificity||This RIOK3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 146-179 amino acids from the Central region of human RIOK3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RIOK3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843).|
|Tissue Location||Widely expressed..|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Anaya P.,et al.Gene 211:323-329(1998).
Nusbaum C.,et al.Nature 437:551-555(2005).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Greenman C.,et al.Nature 446:153-158(2007).
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