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ST3GAL2 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q16842 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40173 Da |
| Gene ID | 6483 |
|---|---|
| Other Names | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferase 2, Alpha 2, 3-ST 2, Beta-galactoside alpha-2, 3-sialyltransferase 2, Gal-NAc6S, Gal-beta-1, 3-GalNAc-alpha-2, 3-sialyltransferase, ST3Gal II, ST3GalII, ST3GalA2, Sialyltransferase 4B, SIAT4-B, ST3GAL2, SIAT4B |
| Target/Specificity | This ST3GAL2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 55-89 amino acids from the N-terminal region of human ST3GAL2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ST3GAL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ST3GAL2 (HGNC:10863) |
|---|---|
| Synonyms | SIAT4B |
| Function | A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8920913, PubMed:9266697). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:25916169, PubMed:8920913, PubMed:9266697). Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8920913, PubMed:9266697). Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell- associated antigen SSEA3, forming SSEA4 (PubMed:12716912). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:25916169, PubMed:9266697). |
| Cellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form distributed along the Golgi cisternae, mainly in proximal compartments (PubMed:25916169). Secreted into the body fluid. {ECO:0000250, ECO:0000269|PubMed:25916169} |
| Tissue Location | Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas Scarcely detectable in lung and kidney. |
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.
References
Kim Y.-J.,et al.Biochem. Biophys. Res. Commun. 228:324-327(1996).
Giordanengo V.,et al.Eur. J. Biochem. 247:558-566(1997).
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$ 192.50
$ 75.00
Cat# AP21060a
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