Mouse Epc1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8C9X6 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 90411 Da |
Gene ID | 13831 |
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Other Names | Enhancer of polycomb homolog 1, Epc1 |
Target/Specificity | This Mouse Epc1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 425-460 amino acids from the Central region of Mouse Epc1. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Epc1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Epc1 {ECO:0000303|PubMed:9735366, ECO:0000312|MGI:MGI:1278322} |
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Function | Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:28694333). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (PubMed:28694333). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (By similarity). |
Cellular Location | Nucleus. Cytoplasm |
Tissue Location | Expressed in adult brain, heart, kidney, liver, lung, skeletal muscle and testis (PubMed:9735366). Expressed in male germ cells, present in round spermatids of steps 1 to 4 (PubMed:28694333). |
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Background
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity).
References
Stankunas K.,et al.Development 125:4055-4066(1998).
Carninci P.,et al.Science 309:1559-1563(2005).
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