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Mouse Nr5a2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Nr5a2 Antibody (Center) AP21181c
    All lanes : Anti-Nr5a2 Antibody (Center) at 1:1000 dilution Lane 1: mouse small intestine lysates Lane 2: rat testis lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 64 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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  • SPECIFICATION
  • CITATIONS: 2
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P45448
Reactivity Mouse, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 64020 Da
Antigen Region 200-233 aa
Additional Information
Gene ID 26424
Other Names Nuclear receptor subfamily 5 group A member 2, Liver receptor homolog 1, LRH-1, Nr5a2, Lrh1
Target/Specificity This Mouse Nr5a2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 200-233 amino acids from the Central region of Mouse Nr5a2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Nr5a2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Nr5a2
Synonyms Lrh1
Function Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti- inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development (By similarity). Activates the transcription of CYP2C38 (PubMed:30555544).
Cellular Location Nucleus {ECO:0000250|UniProtKB:O00482}.
Research Areas
Citations ( 0 )

Background

Binds to promoters containing the sequence element 5'- AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity).

References

Tugwood J.D.,et al.Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
Sablin E.P.,et al.Mol. Cell 11:1575-1585(2003).
Li Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:9505-9510(2005).

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$ 365.00
$ 140.00
Cat# AP21181c
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