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KCNMB2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - KCNMB2 Antibody (C-term) AP21356b
    Anti-KCNMB2 Antibody (C-term)at 1:1000 dilution + HepG2 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 27 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
    detail
  • WB - KCNMB2 Antibody (C-term) AP21356b
    All lanes : Anti-KCNMB2 Antibody (C-term) at 1:2000 dilution Lane 1: human brain lysates Lane 2: mouse brain lysates Lane 3: rat brain lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 27 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y691
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 27130 Da
Additional Information
Gene ID 10242
Other Names Calcium-activated potassium channel subunit beta-2, BK channel subunit beta-2, BKbeta2, Hbeta2, Calcium-activated potassium channel, subfamily M subunit beta-2, Charybdotoxin receptor subunit beta-2, Hbeta3, K(VCA)beta-2, Maxi K channel subunit beta-2, Slo-beta-2, KCNMB2
Target/Specificity This KCNMB2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 174-189 amino acids from the C-terminal region of human KCNMB2.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKCNMB2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNMB2
Function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues
Citations (0)
citation

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Background

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.

References

Wallner M.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:4137-4142(1999).
Brenner R.,et al.J. Biol. Chem. 275:6453-6461(2000).
Xia X.-M.,et al.J. Neurosci. 19:5255-5264(1999).
Meera P.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:5562-5567(2000).
Xia X.-M.,et al.J. Gen. Physiol. 121:125-148(2003).

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$ 182.50
$ 70.00
Cat# AP21356b
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