SYNJ1 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | O43426 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 173103 Da |
Gene ID | 8867 |
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Other Names | Synaptojanin-1, Synaptic inositol 1, 5-trisphosphate 5-phosphatase 1, SYNJ1, KIAA0910 |
Target/Specificity | This SYNJ1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1517-1551 amino acids from the C-terminal region of human SYNJ1. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SYNJ1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SYNJ1 |
---|---|
Synonyms | KIAA0910 |
Function | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:27435091, PubMed:23804563). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). |
Cellular Location | Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O18964} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis.
References
Haffner C.,et al.FEBS Lett. 419:175-180(1997).
Nagase T.,et al.DNA Res. 5:355-364(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Hattori M.,et al.Nature 405:311-319(2000).
Cestra G.,et al.J. Biol. Chem. 274:32001-32007(1999).
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