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Mouse Srms Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q62270 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55758 Da |
| Antigen Region | 113-147 aa |
| Other Names | Tyrosine-protein kinase Srms, PTK70, Srms, Srm |
|---|---|
| Target/Specificity | This Mouse Srms antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 113-147 amino acids from the Central region of Mouse Srms. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Srms Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Srms |
|---|---|
| Synonyms | Srm |
| Function | Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent. Phosphorylates OTUB1, promoting deubiquitination of RPTOR. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9H3Y6}. Note=Localizes to punctate cytoplasmic structures {ECO:0000250|UniProtKB:Q9H3Y6} |
| Tissue Location | Higher expression in liver, lung, thymus and skin than in brain, kidney, heart and spleen (PubMed:9226137). In skin, highly expressed in keratinocytes (PubMed:9226137). Abundant in lung, liver, spleen, kidney and testis and is also detected in the cerebrum (PubMed:7935409). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.
References
Kawachi Y.,et al.Exp. Dermatol. 6:140-146(1997).
Kohmura N.,et al.Mol. Cell. Biol. 14:6915-6925(1994).
Wall M.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
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