FLYWCH1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q4VC44 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 80108 Da |
Antigen Region | 414-447 aa |
Gene ID | 84256 |
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Other Names | FLYWCH-type zinc finger-containing protein 1, FLYWCH1, KIAA1552 |
Target/Specificity | This FLYWCH1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 414-447 amino acids from the Central region of human FLYWCH1. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | FLYWCH1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FLYWCH1 |
---|---|
Synonyms | KIAA1552 |
Function | Transcription cofactor (PubMed:30097457). Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding (PubMed:30097457). May play a role in DNA-damage response signaling (PubMed:33924684). Binds specifically to DNA sequences at peri-centromeric chromatin loci. |
Cellular Location | Nucleus. Chromosome, centromere. Note=Localized to peri-centromeric, H3K9me3-marked heterochromatin |
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Provided below are standard protocols that you may find useful for product applications.
References
Nagase T.,et al.DNA Res. 7:273-281(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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