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Epsin2 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O95208 |
| Other Accession | Q9Z1Z3, Q8CHU3, O88339, Q80VP1, Q9Y6I3, Q8IYW4 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 68482 Da |
| Antigen Region | 6-36 aa |
| Gene ID | 22905 |
|---|---|
| Other Names | Epsin-2, EPS-15-interacting protein 2, EPN2, KIAA1065 |
| Target/Specificity | This Epsin2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-36 amino acids from the N-terminal region of human Epsin2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Epsin2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EPN2 |
|---|---|
| Synonyms | KIAA1065 |
| Function | Plays a role in the formation of clathrin-coated invaginations and endocytosis. |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle. Note=In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex |
| Tissue Location | Highest expression is found in brain. Detected at lower levels in lung and liver. |
Provided below are standard protocols that you may find useful for product applications.
Background
Epsin2 plays a role in the formation of clathrin-coated invaginations and endocytosis. It binds to EPS15 (via the NPF repeat domain), as well as to AP-2 and clathrin (via the DPW repeat domain). The protein resides in the cytoplasm, in punctate structures throughout the cell, associated with clathrin-coated vesicles, and is particularly concentrated in the region of the Golgi complex. Highest expression is found in brain, with lower levels detected in lung and liver.
References
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
Kikuno, R., et al., DNA Res. 6(3):197-205 (1999).
Rosenthal, J.A., et al., J. Biol. Chem. 274(48):33959-33965 (1999).
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