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DLG4 Antibody (C-erm)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DLG4 Antibody (C-erm) AP21835a
    All lanes : Anti-DLG4 Antibody (C-erm) at 1:2000 dilution Lane 1: human brain lysate Lane 2: mouse brain lysate Lane 3: mouse cerebellum lysate Lane 4: rat brain lysate Lane 5: rat cerebellum lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 80 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P78352
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 80495 Da
Additional Information
Gene ID 1742
Other Names Disks large homolog 4, Postsynaptic density protein 95, PSD-95, Synapse-associated protein 90, SAP-90, SAP90, DLG4, PSD95
Target/Specificity This DLG4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 548-579 amino acids from human DLG4.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDLG4 Antibody (C-erm) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DLG4 (HGNC:2903)
Synonyms PSD95
Function Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723).
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Postsynaptic density {ECO:0000250|UniProtKB:P31016}. Synapse Cytoplasm {ECO:0000250|UniProtKB:P31016}. Cell projection, axon {ECO:0000250|UniProtKB:P31016}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P31016}. Cell projection, dendrite {ECO:0000250|UniProtKB:P31016}. Presynapse {ECO:0000250|UniProtKB:P31016}. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4. {ECO:0000250|UniProtKB:P31016}
Tissue Location Brain.
Research Areas
Citations (0)
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Background

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).

References

Stathakis D.G.,et al.Genomics 44:71-82(1997).
Stathakis D.G.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Stathakis D.G.,et al.J. Neurochem. 73:2250-2265(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).

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$ 182.50
$ 70.00
Cat# AP21835a
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