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APC2 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95996 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 243949 Da |
| Gene ID | 10297 |
|---|---|
| Other Names | Adenomatous polyposis coli protein 2, Adenomatous polyposis coli protein-like, APC-like, APC2, APCL |
| Target/Specificity | This APC2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 122-152 amino acids from human APC2. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | APC2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | APC2 (HGNC:24036) |
|---|---|
| Synonyms | APCL |
| Function | Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329). |
| Cellular Location | Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm Cytoplasm, perinuclear region Note=Associated with actin filaments (PubMed:11691822, PubMed:25753423). Associated with microtubule network (PubMed:10644998, PubMed:11691822, PubMed:25753423). |
| Tissue Location | Widely expressed (at protein level). Specifically expressed in the CNS. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.
References
Nakagawa H.,et al.Cancer Res. 58:5176-5181(1998).
Nakagawa H.,et al.Jpn. J. Cancer Res. 90:982-986(1999).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Carr I.M.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
van Es J.H.,et al.Curr. Biol. 9:105-108(1999).
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