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FBXO32 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q969P5 |
| Other Accession | Q2KHT6, Q9CPU7, Q1A730, Q91Z62 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Pig, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41637 Da |
| Gene ID | 114907 |
|---|---|
| Other Names | F-box only protein 32, Atrogin-1, Muscle atrophy F-box protein, MAFbx, FBXO32 |
| Target/Specificity | This FBXO32 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 17-49 amino acids from human FBXO32. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FBXO32 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FBXO32 |
|---|---|
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. |
| Cellular Location | Cytoplasm. Nucleus Note=Shuttles between cytoplasm and the nucleus |
| Tissue Location | Specifically expressed in cardiac and skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
References
Bodine S.C.,et al.Science 294:1704-1708(2001).
Sivertsen E.A.,et al.Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
Pescatori M.,et al.Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
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