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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Phospho Antibodies   >   Bi-Phospho-LLGL1/2(S655/659) /(S645/S649) Antibody   

Bi-Phospho-LLGL1/2(S655/659) /(S645/S649) Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Bi-Phospho-LLGL1/2(S655/659) /(S645/S649) Antibody AP2198a
    The anti-Phospho-LLGL1/2 Pab (Cat. #AP2198a) is used for detection against A2058 cell line lysate. Phospho-LLGL1/2(arrow) was detected using the purified Pab.
  • SPECIFICATION
  • CITATIONS: 2
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q15334, Q6P1M3
Other Accession Q3TJ91, Q8K4K5, Q80Y17, Q15334, Q8MKF0, Q6P1M3
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional Information
Other Names Lethal(2) giant larvae protein homolog 2, HGL, LLGL2
Target/Specificity This LLGL1/2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S645/S649 of human LLGL1/2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBi-Phospho-LLGL1/2(S655/659) /(S645/S649) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Research Areas
Citations ( 0 )

Background

LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.

References

Schimanski, C.C., et al., Oncogene 24(19):3100-3109 (2005). Grifoni, D., et al., Oncogene 23(53):8688-8694 (2004). Katoh, M., et al., Int. J. Oncol. 24(3):737-742 (2004). Bi, W., et al., Genome Res. 12(5):713-728 (2002). Ludford-Menting, M.J., et al., J. Biol. Chem. 277(6):4477-4484 (2002). Yasumi, M., et al., J. Biol. Chem. 280(8):6761-6765 (2005).

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Discontinued
Cat# AP2198a
Size:

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