Bi-Phospho-LLGL1/2(S655/659) /(S645/S649) Antibody
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
- CITATIONS: 2
|Application ||WB, E|
|Primary Accession||Q15334, Q6P1M3|
|Other Accession||Q3TJ91, Q8K4K5, Q80Y17, Q15334, Q8MKF0, Q6P1M3|
|Predicted||Bovine, Mouse, Rat|
|Other Names||Lethal(2) giant larvae protein homolog 2, HGL, LLGL2|
|Target/Specificity||This LLGL1/2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S645/S649 of human LLGL1/2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Bi-Phospho-LLGL1/2(S655/659) /(S645/S649) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Provided below are standard protocols that you may find useful for product applications.
LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.
Schimanski, C.C., et al., Oncogene 24(19):3100-3109 (2005). Grifoni, D., et al., Oncogene 23(53):8688-8694 (2004). Katoh, M., et al., Int. J. Oncol. 24(3):737-742 (2004). Bi, W., et al., Genome Res. 12(5):713-728 (2002). Ludford-Menting, M.J., et al., J. Biol. Chem. 277(6):4477-4484 (2002). Yasumi, M., et al., J. Biol. Chem. 280(8):6761-6765 (2005).
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