SLC6A8 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P48029 |
Other Accession | O18875, Q8VBW1, P28570 |
Reactivity | Mouse |
Predicted | Bovine, Rat |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 70523 Da |
Gene ID | 6535 |
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Other Names | Sodium- and chloride-dependent creatine transporter 1, CT1, Creatine transporter 1, Solute carrier family 6 member 8, SLC6A8 |
Target/Specificity | This SLC6A8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 180-212 amino acids from human SLC6A8. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SLC6A8 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC6A8 |
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Function | Creatine:sodium symporter which mediates the uptake of creatine (PubMed:7953292, PubMed:7945388, PubMed:9882430, PubMed:17465020, PubMed:22644605, PubMed:25861866). Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein |
Tissue Location | Predominantly expressed in skeletal muscle and kidney. Also found in brain, heart, colon, testis and prostate |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for the uptake of creatine in muscles and brain.
References
Nash S.R.,et al.Recept. Channels 2:165-174(1994).
Sora I.,et al.Biochem. Biophys. Res. Commun. 204:419-427(1994).
Sandoval N.,et al.Genomics 35:383-385(1996).
Barnwell L.F.,et al.Gene 159:287-288(1995).
Martinez-Munoz C.,et al.Gene 418:53-59(2008).
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