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NOP2 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P46087 |
| Other Accession | Q922K7 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 89302 Da |
| Gene ID | 4839 |
|---|---|
| Other Names | Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase, 2.1.1.-, Nucleolar protein 1, Nucleolar protein 2 homolog, Proliferating-cell nucleolar antigen p120, Proliferation-associated nucleolar protein p120, NOP2, NOL1, NSUN1 |
| Target/Specificity | This NOP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 9-43 amino acids from human NOP2. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NOP2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NOP2 |
|---|---|
| Synonyms | NOL1, NSUN1 |
| Function | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). |
| Cellular Location | Nucleus, nucleolus. Nucleus Note=Localizes predominantly in the nucleolus and to a smaller extent in the nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation.
References
Fonagy A.,et al.Cancer Commun. 1:243-251(1989).
Larson R.G.,et al.Cancer Commun. 2:63-71(1990).
Valdez B.C.,et al.Cancer Res. 52:5681-5686(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
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