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PGAP1 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, FC, E |
|---|---|
| Primary Accession | Q75T13 |
| Other Accession | Q3UUQ7, Q765A7 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 105383 Da |
| Gene ID | 80055 |
|---|---|
| Other Names | GPI inositol-deacylase, 3.1.-.-, Post-GPI attachment to proteins factor 1, hPGAP1, PGAP1 |
| Target/Specificity | This PGAP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 90-122 amino acids from human PGAP1. |
| Dilution | WB~~1:2000 IF~~1:25 FC~~1:25 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PGAP1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PGAP1 (HGNC:25712) |
|---|---|
| Function | GPI inositol-deacylase that catalyzes the remove of the acyl chain linked to the 2-OH position of inositol ring from the GPI- anchored protein (GPI-AP) in the endoplasmic reticulum (PubMed:24784135, PubMed:38167496). Initiates the post-attachment remodeling phase of GPI-AP biogenesis and participates in endoplasmic reticulum (ER)-to-Golgi transport of GPI-anchored protein (PubMed:24784135, PubMed:38167496). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q765A7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q765A7} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity).
References
Tanaka S.,et al.J. Biol. Chem. 279:14256-14263(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Hillier L.W.,et al.Nature 434:724-731(2005).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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