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IL11 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P20809 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21429 Da |
| Gene ID | 3589 |
|---|---|
| Other Names | Interleukin-11, IL-11, Adipogenesis inhibitory factor, AGIF, Oprelvekin, IL11 |
| Target/Specificity | This IL11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 27-61 amino acids from human IL11. |
| Dilution | WB~~1:2000 FC~~1:25 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IL11 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IL11 (HGNC:5966) |
|---|---|
| Function | Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168). |
| Cellular Location | Secreted |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
References
Paul S.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7512-7516(1990).
Kawashima I.,et al.FEBS Lett. 283:199-202(1991).
McKinley D.,et al.Genomics 13:814-819(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
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