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CD59 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IF, IHC-P-Leica, E |
|---|---|
| Primary Accession | P13987 |
| Other Accession | Q28216 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 14177 Da |
| Gene ID | 966 |
|---|---|
| Other Names | CD59 glycoprotein, 1F5 antigen, 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-inhibitory protein, MAC-IP, MEM43 antigen, Membrane attack complex inhibition factor, MACIF, Membrane inhibitor of reactive lysis, MIRL, Protectin, CD59, CD59, MIC11, MIN1, MIN2, MIN3, MSK21 |
| Target/Specificity | This CD59 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 74-110 amino acids from the Central region of human CD59. |
| Dilution | IF~~1:25 WB~~1:2000 IHC-P-Leica~~1:1000 IHC~~1:250 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CD59 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD59 |
|---|---|
| Synonyms | MIC11, MIN1, MIN2, MIN3, MSK21 |
| Function | Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Soluble form found in a number of tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
References
Davies A.,et al.J. Exp. Med. 170:637-654(1989).
Philbrick W.M.,et al.Eur. J. Immunol. 20:87-92(1990).
Okada H.,et al.Biochem. Biophys. Res. Commun. 162:1553-1559(1989).
Sugita Y.,et al.J. Biochem. 106:555-557(1989).
Sawada R.,et al.DNA Cell Biol. 9:213-220(1990).
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