CLCN1 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC, E |
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Primary Accession | P35523 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 108626 Da |
Gene ID | 1180 |
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Other Names | Chloride channel protein 1, ClC-1, Chloride channel protein, skeletal muscle, CLCN1, CLC1 |
Target/Specificity | This CLCN1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-66 amino acids from the human region of human CLCN1. |
Dilution | WB~~1:2000 FC~~1:25 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CLCN1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CLCN1 (HGNC:2019) |
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Synonyms | CLC1 |
Function | Voltage-gated chloride channel (PubMed:8112288, PubMed:9122265, PubMed:12456816). Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (Probable). The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Predominantly expressed in skeletal muscles. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
References
Steinmeyer K.,et al.EMBO J. 13:737-743(1994).
Scherer S.W.,et al.Science 300:767-772(2003).
Koch M.C.,et al.Science 257:797-800(1992).
George A.L. Jr.,et al.Nat. Genet. 3:305-310(1993).
Lorenz C.,et al.Hum. Mol. Genet. 3:941-946(1994).
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