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KIAA1524 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8TCG1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 102185 Da |
| Gene ID | 57650 |
|---|---|
| Other Names | Protein CIP2A, Cancerous inhibitor of PP2A, p90 autoantigen, KIAA1524, CIP2A |
| Target/Specificity | This KIAA1524 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 537-567 amino acids from the Central region of human KIAA1524. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KIAA1524 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CIP2A {ECO:0000303|PubMed:17632056, ECO:0000312|HGNC:HGNC:29302} |
|---|---|
| Function | Acts as an inhibitor of protein phosphatase PP2A (PubMed:17632056). Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies (PubMed:17632056). Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). |
| Cellular Location | Cytoplasm. Chromosome. Note=Predominantly localizes within the cytoplasm (PubMed:35842428). Localizes to broken chromosomes within micronuclei during interphase and following chromothripsis (PubMed:37165191, PubMed:37316668). Localization to broken chromosomes is mainly independent of MDC1 (PubMed:35121901, PubMed:37165191) |
| Tissue Location | Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC) Present in liver cancer cells (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.
References
Soo Hoo L.,et al.Oncogene 21:5006-5015(2002).
Nagase T.,et al.DNA Res. 7:143-150(2000).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Shi F.D.,et al.Prostate 63:252-258(2005).
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