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ZBTB16(Y334)Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q05516 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit Ig |
| Calculated MW | 74274 Da |
| Gene ID | 7704 |
|---|---|
| Other Names | Zinc finger and BTB domain-containing protein 16, Promyelocytic leukemia zinc finger protein, Zinc finger protein 145, Zinc finger protein PLZF, ZBTB16, PLZF, ZNF145 |
| Target/Specificity | This ZBTB16(Y334) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human ZBTB16(Y334). |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZBTB16(Y334)Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZBTB16 |
|---|---|
| Synonyms | PLZF, ZNF145 |
| Function | Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). |
| Cellular Location | Nucleus. Nucleus, nuclear body |
| Tissue Location | Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung |
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Background
Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).
References
Chen Z.,et al.EMBO J. 12:1161-1167(1993).
Zhang T.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:11422-11427(1999).
Chen S.-J.,et al.J. Clin. Invest. 91:2260-2267(1993).
Hoatlin M.E.,et al.Blood 94:3737-3747(1999).
Melnick A.M.,et al.Mol. Cell. Biol. 20:2075-2086(2000).
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