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GPC4 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O75487 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 62412 Da |
| Antigen Region | 395-422 aa |
| Gene ID | 2239 |
|---|---|
| Other Names | Glypican-4, K-glypican, Secreted glypican-4, GPC4 |
| Target/Specificity | This GPC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-422 amino acids from the Central region of human GPC4. |
| Dilution | WB~~1:500 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPC4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPC4 |
|---|---|
| Function | Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.
References
Karumanchi,S.A., Mol. Cell 7 (4), 811-822 (2001)
Hagihara,K., Dev. Dyn. 219 (3), 353-367 (2000)
Veugelers,M., Hum. Mol. Genet. 9 (9), 1321-1328 (2000)
Veugelers,M., Genomics 53 (1), 1-11 (1998)
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