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SNURF Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9Y675 |
| Other Accession | Q9XS97, Q9WU12, Q9XS96 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 8412 Da |
| Antigen Region | 4-32 aa |
| Gene ID | 8926 |
|---|---|
| Other Names | SNRPN upstream reading frame protein, SNURF |
| Target/Specificity | This SNURF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the Central region of human SNURF. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SNURF Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNURF |
|---|---|
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in heart, skeletal muscle and lymphoblasts (at protein level). Expressed in brain, pancreas, heart, liver, lung, kidney and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SNURF is a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame of its gene is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center. Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region but the full-length nature of these transcripts has not been determined. An alternate exon has been identified that substitutes for exon 4 and leads to a truncated, monocistronic transcript. Alternative splicing or deletion caused by a translocation event in the 5' UTR or coding region of this gene leads to Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. The function of this protein is not yet known.
References
Rodriguez-Jato,S., Nucleic Acids Res. 33 (15), 4740-4753 (2005)
Runte,M., Hum. Genet. 114 (6), 553-561 (2004)
Runte,M., Hum. Mol. Genet. 10 (23), 2687-2700 (2001)
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