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CCNB2 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95067 |
| Other Accession | Q4R7A8 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45282 Da |
| Antigen Region | 101-128 aa |
| Gene ID | 9133 |
|---|---|
| Other Names | G2/mitotic-specific cyclin-B2, CCNB2 |
| Target/Specificity | This CCNB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-128 amino acids from the Central region of human CCNB2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCNB2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCNB2 |
|---|---|
| Function | Essential for the control of the cell cycle at the G2/M (mitosis) transition. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.
References
De Martino,I., Cancer Res. 69 (5), 1844-1850 (2009)
Bellanger,S., Oncogene 26 (51), 7175-7184 (2007)
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