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> home > Products > Primary Antibodies > Antibody Collections > Host cell receptor for virus entry > CXADR Antibody (Center)
CXADR Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P78310 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40030 Da |
| Antigen Region | 132-161 aa |
| Gene ID | 1525 |
|---|---|
| Other Names | Coxsackievirus and adenovirus receptor, CAR, hCAR, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, HCVADR, CXADR, CAR |
| Target/Specificity | This CXADR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-161 amino acids from the Central region of human CXADR. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CXADR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CXADR |
|---|---|
| Synonyms | CAR |
| Function | Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3- kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797). [Isoform 4]: Secreted |
| Tissue Location | Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. |
Research Areas
Citations (0)
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Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
CXADR is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses.
References
Tomko R.P., Xu R., Philipson L.Proc. Natl. Acad. Sci. U.S.A. 94:3352-3356(1997)
Bowles K.R., Gibson J.,Hum. Genet. 105:354-359(1999)
Fechner H., Haack A., Wang H., Wang X.Gene Ther. 6:1520-1535(1999)
Martino T.A., Petric M., Weingartl H.Virology 271:99-108(2000)
Ashbourne-Excoffon K.J.D., Hruska-Hageman A.M.J. Cell Sci. 117:4401-4409(2004)
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$ 365.00
$ 140.00
Cat# AP2852c
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