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Phospho-CCNB3(T280) Antibody
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| DB, E |
|---|---|
| Primary Accession | Q8WWL7 |
| Other Accession | NP_149020.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 157916 Da |
| Gene ID | 85417 |
|---|---|
| Other Names | G2/mitotic-specific cyclin-B3, CCNB3, CYCB3 |
| Target/Specificity | This CCNB3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T280 of human CCNB3. |
| Dilution | DB~~1:500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Phospho-CCNB3(T280) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCNB3 |
|---|---|
| Synonyms | CYCB3 |
| Function | Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I. |
| Cellular Location | Nucleus. |
| Tissue Location | Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chick and Drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and be required for proper spindle reorganization and restoration of the interphase nucleus. Two transcript variants encoding different isoforms have been found for this gene.
References
Cheng, J., et al. Science 308(5725):1149-1154(2005)
Nguyen, T.B., et al. J. Biol. Chem. 277(44):41960-41969(2002)
Hrimech, M., et al. EMBO J. 21 (14), 3918 (2002) :
Lozano, J.C., et al. Biochem. Biophys. Res. Commun. 291(2):406-413(2002)
Mouland, A.J., et al. Virology 292(2):321-330(2002)
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