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LUZP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q86V48 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 120275 Da |
| Antigen Region | 1042-1070 aa |
| Gene ID | 7798 |
|---|---|
| Other Names | Leucine zipper protein 1, LUZP1 |
| Target/Specificity | This LUZP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1042-1070 amino acids from the C-terminal region of human LUZP1. |
| Dilution | FC~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LUZP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LUZP1 |
|---|---|
| Function | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up- regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Midbody. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, stress fiber. Nucleus {ECO:0000250|UniProtKB:Q9ESV1} Cell projection, dendrite {ECO:0000250|UniProtKB:Q9ESV1}. Perikaryon {ECO:0000250|UniProtKB:Q9ESV1}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q8R4U7}. Note=Localizes to the proximal end of basal bodies (PubMed:32496561). During mitosis, localizes at the inner centromere in metaphase, at the central spindle in anaphase, and at the midbody in telophase (PubMed:38009294). Central spindle localization requires KIF20A while centromere localization requires the kinase activity of the chromosomal passenger complex (PubMed:38009294) |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
LUZP1 encodes a protein that contains a leucine zipper motif. The exact function of the encoded protein is not known. In mice this gene affects neural tube closure.
References
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Jikuya, H., et al. DNA Res. 10(1):49-57(2003)
Sun, D.S., et al. Genomics 36(1):54-62(1996)
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$ 150.00
$ 385.00
Cat# AP4711b
Ordering Information
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