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GSDMA Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | Q96QA5 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49365 Da |
| Antigen Region | 66-94 aa |
| Gene ID | 284110 |
|---|---|
| Other Names | Gasdermin-A, Gasdermin-1, GSDMA, GSDM, GSDM1 |
| Target/Specificity | This GSDMA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human GSDMA. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GSDMA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GSDMA (HGNC:13311) |
|---|---|
| Function | [Gasdermin-A]: This form constitutes the precursor of the pore-forming protein and acts as a sensor of infection: upon infection by S.pyogenes, specifically cleaved by S.pyogenes effector protein SpeB in epithelial cells, releasing the N-terminal moiety (Gasdermin-A, N- terminal) that binds to membranes and forms pores, triggering pyroptosis. |
| Cellular Location | [Gasdermin-A]: Cytoplasm, perinuclear region. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5Y4Y6} |
| Tissue Location | Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and mucus-secreting pit cells of the gastric epithelium Down-regulated in gastric cancer cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
GSDMA induces apoptosis.
References
Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)
Saeki, N., et al. Genes Chromosomes Cancer 48(3):261-271(2009)
Tamura, M., et al. Genomics 89(5):618-629(2007)
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