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MILK2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q8IY33 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 97502 Da |
| Antigen Region | 841-870 aa |
| Gene ID | 79778 |
|---|---|
| Other Names | MICAL-like protein 2, Junctional Rab13-binding protein, Molecule interacting with CasL-like 2, MICAL-L2, MICALL2, JRAB |
| Target/Specificity | This MILK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 841-870 amino acids from the C-terminal region of human MILK2. |
| Dilution | FC~~1:10~50 IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MILK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MICALL2 (HGNC:29672) |
|---|---|
| Synonyms | JRAB |
| Function | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q3TN34}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3TN34}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q3TN34}. Recycling endosome {ECO:0000250|UniProtKB:Q3TN34}. Cell projection {ECO:0000250|UniProtKB:Q3TN34}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q3TN34} |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
MILK2 may be a cytoskeletal regulator.
References
Kanda, I., et al. Oncogene 27(12):1687-1695(2008)
Terai, T., et al. Mol. Biol. Cell 17(5):2465-2475(2006)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Terman, J.R., et al. Cell 109(7):887-900(2002)
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$ 150.00
$ 385.00
Cat# AP4901b
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