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OPN1MW Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | P04001 |
| Other Accession | O12948, P04000, P22329, O35476, P0DN77, P0DN78 |
| Reactivity | Human |
| Predicted | Rat, Chicken, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40584 Da |
| Antigen Region | 21-50 aa |
| Gene ID | 101060233;2652;728458 |
|---|---|
| Other Names | Medium-wave-sensitive opsin 1, Green cone photoreceptor pigment, Green-sensitive opsin, GOP, OPN1MW, GCP |
| Target/Specificity | This OPN1MW antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human OPN1MW. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OPN1MW Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OPN1MW (HGNC:4206) |
|---|---|
| Synonyms | GCP |
| Function | Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | The three color pigments are found in the cone photoreceptor cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
OPN1MW encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness.
References
Thirumuruganandham, S.P., et al. J Mol Model 15(8):959-969(2009)
Ala-Laurila, P., et al. J. Biol. Chem. 284(24):16492-16500(2009)
Holmes, M.V., et al. PLoS ONE 4 (12), E7960 (2009)
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