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PTPLB Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | Q6Y1H2 |
| Other Accession | Q2KIP8, NP_940684 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28368 Da |
| Antigen Region | 226-254 aa |
| Gene ID | 201562 |
|---|---|
| Other Names | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2, 3-hydroxyacyl-CoA dehydratase 2, HACD2, Protein-tyrosine phosphatase-like member B, PTPLB, HACD2 |
| Target/Specificity | This PTPLB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 amino acids from the C-terminal region of human PTPLB. |
| Dilution | WB~~1:1000 FC~~1:10~50 IHC-P~~1:50~100 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PTPLB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HACD2 {ECO:0000303|PubMed:18554506, ECO:0000312|HGNC:HGNC:9640} |
|---|---|
| Function | Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in testis, spleen, prostate, colon and heart, followed by moderate expression in thymus, ovary, small intestine, peripheral blood leukocytes, liver, skeletal muscle and pancreas. Weakly detected in kidney, placenta, brain and lung |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
PTPLB is probable anti-phosphatase.
References
Wang, B., et al. Mol. Cell. Biol. 24(7):2767-2778(2004)
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$ 150.00
$ 385.00
Cat# AP4975b
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