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ADCY9 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | O60503 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 151 KDa |
| Antigen Region | 955-983 aa |
| Gene ID | 115 |
|---|---|
| Other Names | Adenylate cyclase type 9, ATP pyrophosphate-lyase 9, Adenylate cyclase type IX, Adenylyl cyclase 9, ADCY9, KIAA0520 |
| Dilution | WB~~ 1:1000 IHC~~1:50-1:100 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | ADCY9 |
|---|---|
| Synonyms | KIAA0520 |
| Function | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:10987815, PubMed:9628827) Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952). |
Provided below are standard protocols that you may find useful for product applications.
Background
May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity).
References
Hacker B.M.,et al.Genomics 50:97-104(1998).
Small K.M.,et al.Pharmacogenetics 13:535-541(2003).
Tantisira K.G.,et al.Hum. Mol. Genet. 14:1671-1677(2005).
Paterson J.M.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
Toyota T.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
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