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CLCC1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q96S66 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 62,56,47,40 KDa |
| Antigen Region | 410-436 aa |
| Gene ID | 23155 |
|---|---|
| Other Names | Chloride channel CLIC-like protein 1, Mid-1-related chloride channel protein 1, CLCC1, KIAA0761, MCLC |
| Dilution | WB~~ 1:500 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | CLCC1 {ECO:0000303|PubMed:37142673, ECO:0000312|HGNC:HGNC:29675} |
|---|---|
| Function | Anion-selective channel with Ca(2+)-dependent and voltage- independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:25698737, PubMed:30157172, PubMed:37142673). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Within the endoplasmic reticulum (ER), localizes to the mitochondria-associated ER membrane, a zone of contact between the ER and mitochondrial membranes. Enriched in the rough ER. {ECO:0000250|UniProtKB:Q99LI2, ECO:0000269|PubMed:31653868} |
| Tissue Location | Expressed in the retina of the eye, with extensive expression in the lamina cribrosa, optic nerve, ganglion cell layer, inner nuclear layer, outer nuclear layer and retinal pigment epithelium. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Seems to act as a chloride ion channel (By similarity).
References
Nagasawa M.,et al.J. Biol. Chem. 276:20413-20418(2001).
Nagase T.,et al.DNA Res. 5:277-286(1998).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Olsen J.V.,et al.Cell 127:635-648(2006).
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