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FOLH1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q04609 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 84331 Da |
| Antigen Region | 155-183 aa |
| Gene ID | 2346 |
|---|---|
| Other Names | Putative N-acetylated-alpha-linked acidic dipeptidase, NAALADase, 34--, Cell growth-inhibiting gene 26 protein, Prostate-specific membrane antigen-like protein, Putative folate hydrolase 1B, FOLH1B, PSMAL |
| Target/Specificity | This FOLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-183 amino acids from the central region of human FOLH1. |
| Dilution | WB~~1:1000 IHC-P~~1:25 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FOLH1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FOLH1 (HGNC:3788) |
|---|---|
| Synonyms | FOLH, NAALAD1, PSM, PSMA |
| Function | Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-9 is specifically expressed in prostate cancer |
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Provided below are standard protocols that you may find useful for product applications.
Background
PSMAL has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity (By similarity). PSMAL exhibits a dipeptidyl-peptidase IV type activity
References
O'Keefe, D.S., et al. Prostate 58(2):200-210(2004)
O'Keefe, D.S., et al. Biochim. Biophys. Acta 1443 (1-2), 113-127 (1998)
Maraj, B.H., et al. Cytogenet. Cell Genet. 81(1):3-9(1998)
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