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MtSSB Antibody
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF |
|---|---|
| Primary Accession | Q04837 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 17 KDa |
| Antigen Region | 86-115 aa |
| Gene ID | 6742 |
|---|---|
| Other Names | Single-stranded DNA-binding protein, mitochondrial, Mt-SSB, MtSSB, PWP1-interacting protein 17, SSBP1, SSBP |
| Dilution | IF~~1:100 WB~~1:1000 IHC~~1:50-100 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | SSBP1 |
|---|---|
| Synonyms | SSBP |
| Function | Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262, PubMed:31550240). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork (PubMed:12975372, PubMed:15167897, PubMed:21953457, PubMed:26446790, PubMed:31550240). Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:21953457, PubMed:26446790, PubMed:31550240). In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372). May also function in mtDNA repair (PubMed:23290262). |
| Cellular Location | Mitochondrion Mitochondrion matrix, mitochondrion nucleoid |
| Tissue Location | Expressed in retinal ganglion cells, photoreceptors, pigmented epithelium and fibroblasts (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.
References
Tiranti V.,et al.Gene 126:219-225(1993).
Honore B.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Xu G.,et al.Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009).
Matsuoka S.,et al.Science 316:1160-1166(2007).
Bogenhagen D.F.,et al.J. Biol. Chem. 283:3665-3675(2008).
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