Aggrecan Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P16112 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 44 KDa |
Gene ID | 176 |
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Other Names | Aggrecan core protein, Cartilage-specific proteoglycan core protein, CSPCP, Chondroitin sulfate proteoglycan core protein 1, Chondroitin sulfate proteoglycan 1, Aggrecan core protein 2, ACAN, AGC1, CSPG1, MSK16 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | ACAN |
---|---|
Synonyms | AGC1, CSPG1, MSK16 |
Function | This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. |
Cellular Location | Secreted, extracellular space, extracellular matrix |
Tissue Location | Detected in fibroblasts (at protein level) (PubMed:36213313). Restricted to cartilage (PubMed:7524681) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
References
Doege K.J.,et al.J. Biol. Chem. 266:894-902(1991).
Ilic M.Z.,et al.Arch. Biochem. Biophys. 322:22-30(1995).
Sandy J.D.,et al.J. Clin. Invest. 89:1512-1516(1992).
Glumoff V.,et al.Biochim. Biophys. Acta 1219:613-622(1994).
Lohmander L.S.,et al.Arthritis Rheum. 36:1214-1222(1993).
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