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APLP1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P51693 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 72 KDa |
| Gene ID | 333 |
|---|---|
| Other Names | Amyloid-like protein 1, APLP, APLP-1, C30, APLP1 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | APLP1 |
|---|---|
| Function | May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD) |
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Provided below are standard protocols that you may find useful for product applications.
Background
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
References
Paliga K.,et al.Eur. J. Biochem. 250:354-363(1997).
Lenkkeri U.,et al.Hum. Genet. 102:192-196(1998).
Grimwood J.,et al.Nature 428:529-535(2004).
Kim T.-W.,et al.Brain Res. Mol. Brain Res. 32:36-44(1995).
Bush A.I.,et al.J. Biol. Chem. 269:26618-26621(1994).
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