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Complement C9 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P02748 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 71 KDa |
| Gene ID | 735 |
|---|---|
| Other Names | Complement component C9, Complement component C9a, Complement component C9b, C9 |
| Dilution | WB~~1:1000 IHC-P~~N/A E~~N/A |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | C9 {ECO:0000303|PubMed:4018030, ECO:0000312|HGNC:HGNC:1358} |
|---|---|
| Function | Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:26841934, PubMed:27052168, PubMed:30552328, PubMed:6177822, PubMed:9212048, PubMed:9634479). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:9212048, PubMed:9634479). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:9212048, PubMed:9634479). Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore (PubMed:26841934, PubMed:30111885, PubMed:30552328, PubMed:34752492, PubMed:4055801, PubMed:6177822). |
| Cellular Location | Secreted. Target cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer (PubMed:26841934, PubMed:30111885, PubMed:4055801, PubMed:9634479) Oligomerizes at target membranes, forming a pre-pore (PubMed:26841934, PubMed:30111885, PubMed:31061395, PubMed:4055801, PubMed:9634479). A conformation change then leads to the formation of a 100 Angstrom diameter pore (PubMed:26841934, PubMed:30111885, PubMed:31061395, PubMed:4055801, PubMed:9634479). |
| Tissue Location | Plasma (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
References
Stanley K.K.,et al.EMBO J. 4:375-382(1985).
Discipio R.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 81:7298-7302(1984).
Marazziti D.,et al.Biochemistry 27:6529-6534(1988).
Witzel-Schloemp K.,et al.Immunogenetics 48:144-147(1998).
DiScipio R.G.,et al.J. Biol. Chem. 260:14802-14809(1985).
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